Randhawa et al reported risk factors for mechanical ventilation in children with Guillain-Barre Syndrome (GBS) in India. These can help to identify a patient who may require more aggressive management. The authors are multiple institutions in India and England.

Patient selection: 1 month to 12 years of age with Guillain-Barre Syndrome


Frequency of mechanical ventilation: 52%


Exam: MRC grading for muscle strength


All patients received intravenous immunoglobulin (IVIg) on admission.


Predictors on admission associated with mechanical ventilation:

(1) upper limb power <= 3 (OR 3.5)

(2) lower limb power <= 2 (OR 3.5)

(3) cranial nerve palsy (OR 3.2)


Predictors on admission associated with mechanical ventilation for > 21 days:

(1) upper limb power <= 2 (OR 4.2)

(2) lower limb power <= 1 (OR 4.5)

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