Predictors of Prevost et al for Mortality in a Patient with a Non-Small Cell Lung Cancer (NSCLC)

Description

Prevost et al identified a number of predictors for mortality in a patient with a non-small cell lung cancer (NSCLC). Hypermetabolism of the bone marrow as detected by 18F-FDG PET scan was associated with increased mortality. The authors are from Universitaire de Sherbrooke and Universitaire de Montreal in Quebec, Canada.

Patient selection: non-small cell lung cancer, excluding those with recurrent or metastatic disease

Patient assessment: complete blood count (CBC) and 18F-FDG PET scan

Parameters associated with mortality from the multivariate analysis:

(1) bone marrow metabolism on PET scan (based on SUV)

(2) nodal stage on the PET scan

(3) hemoglobin

(4) platelet count

(5) white blood cell count

Parameter	Finding	Points
bone marrow metabolism	normal or low uptake	0
	hypermetabolic (SUV >= 1.7 adjusted for lean body mass)	1
nodal stage	N0 or N1	0
	N2 or N3	1
hemoglobin	>= 9 g/dL	0
	< 9 g/dL	1
platelet count	normal	0
	thrombocytopenia or thrombocytosis	1
white blood cell count	< 12,500 per µL	0
	>= 12,500 per µL	1

where:

• A patient with N0 or N1 is a potential candidate for surgical resection. People who underwent surgical resection had a better survival.

number of findings associated with a worse prognosis =

= SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score the shorter the survival.

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Description

Specialty

ICD-10