Mottl et al reported factors predictive of progression to end-stage renal disease (ESRD) in a patient with diabetic nephropathy. These can help to identify a patient who benefit from more aggressive management. The authors are from the University of North Carolina.
Patient selection: diabetic nephropathy
Predictors from multivariate analysis:
(1) segmental sclerosis = SS (subdistribution HR 2.0)
Extracapillary hypercellularity occurs at sites of rupture of dilated capillaries following mesangiolysis. Ut was defined as more than 2 layers of epithelial cells affecting > 10% of the surface of the glomerular tuft or Bowman's capsule and comprising > 10% cells.
