Patient selection: older adult >= 65 years with a solid organ cancer
Outcome: toxicity grade >= 3, hematological or non-hematological
Most common non-hematologic toxicities: non-neutropenic infection, fatigue, nausea
Predictors of severe chemotherapy-related toxicity:
(1) Short Blessed Orientation Memory Concentration Test abnormal (>= 5; OR 2.7)
(2) timed up and go test >= 14 seconds (OR 4.2)
(3) impaired social activity due to health
Neither the CARG Toxicity Score nor the oncologist's estimate of risk were predictive of severe toxicity.
It is unclear if the predictors are causal or if they merely reflect the behaviors shown by a patient with severe toxicity.
