A subset of patients with ocular myasthenia gravis will experience progression to generalized myasthenia over a few years. Mazzoli et al identified factors which can help to identify a patient at increased risk for this progression. The authors are from University Hospital and University of Modena and Reggio-Emilia in Italy.
Patient selection: ocular myasthenia
Outcome: progression to generalized myasthenia and/or bulbar symptoms
Predictors of progression:
(1) female gender
(2) age of onset for the ocular myasthenia > 50 years
(3) presence of antibodies to acetylcholine receptors (AChR)
The risk for progression increased with the number of predictors.
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