Description

Manini et al listed ECG changes associated with adverse cardiovascular events in a patient with acute poisoning. The authors are from Mount Sinai School of Medicine, New York University and the New York City Poison Control Center.


Patient selection: suspected poisoning

 

Outcome: adverse cardiovascular event (shock, myocardial injury, dysrhythmia, cardiac arrest)

 

Parameters:

(1) presence of ectopy

(2) rhythm (sinus vs nonsinus)

(3) QTc interval in ms

(4) sex

 

Ectopy

Rhythm

QTc

Risk

present

NA

NA

high

absent

nonsinus

NA

moderate

absent

sinus

>= 500 ms

moderate

absent

sinus

above normal but <= 500 ms

low

absent

sinus

normal

very low

 

where:

The upper limit of normal for QTc was 469 ms for females and 449 ms for males.

 

Risk

Adverse Cardiovascular Events

high

64%

moderate

>38%

low

26%

very low

4%

 

Other risk factors for adverse cardiovascular events:

(1) QT dispersion (difference between the longest and shortest QT interval) >= 50 ms

(2) ischemia or infarction


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