Description

Lin et al evaluated patients with acute on chronic liver failure for hemorrhagic complications after abdominal paracentesis. A patient at increased risk may benefit from more aggressive management. The authors are from the First Affiliated Hospital of Fujian Medical University and Huashan Hospital of Fudan University in China.


Patient selection: acute-on-chronic liver failure (ACLF)

 

Hemorrhagic complications included:

(1) hemorrhagic ascites during or after the procedure (fluid RBC count > 10 * 10^9/L)

(2) abdominal wall hematoma

 

The diagnosis required presence within 7 days of the procedure and no other explanation.

 

The source of bleeding is presumed to be from either a vessel in the abdominal wall or mesenteric varices.

 

A patient was at risk for hemorrhagic complications if both of the following are present:

(1) MELD score > 25

(2) plasma fibrinogen <= 0.7 g/L (70 mg/dL)

 

Performance:

• The area under the ROC curve was 0.73 for fibrinogen concentrations.

• The positive predictive value was 36.5%.


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