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Description

Li et al evaluated adverse pregnancy outcomes in pregnant women with syphilis in China. The authors are from the National Centre for Women and Children Health in Beijing.


Patient selection: pregnant woman with syphilis

 

Adverse pregnancy outcomes:

(1) stillbirth

(2) preterm birth

(3) neonatal death

(4) congenital syphilis

 

Criteria for congenital syphilis - one or more of the following:

(1) direct visualization of T. pallidum in a clinical specimen (dark field, other)

(2) IgM-positive reactive treponemal antibody test

(3) positive treponemal test in neonate AND titer of non-treponemal test (RPR, TRUST) >= 4 times higher than that of the mother before delivery

 

Predictors of adverse pregnancy outcomes on multivariate analysis:

(1) diagnosis at any time after first trimester (HR 4.1 in second trimester and 26.7 postpartum)

(2) coinfection with HBV (HR 2.4)

(3) not accepting standardized or non-standardized treatment


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