Patient selection: opioid prescription for pain
Outcome: addiction
Factors associated with a higher risk for addiction:
(1) history of opioid use disorder (likelihood ratio 17-22)
(2) history of other substance use disorder (likelihood ratio 4.3-17)
(3) mental health diagnoses (see below)
(4) concomitant prescriptions (see below)
(5) duration of opioid therapy >= 30 days
(6) higher daily opioid dose (> 120 mg per day)
Mental health diagnoses:
(1) personality disorder (likelihood ratio 27)
(2) mood disorder
(3) somatoform disorder
(4) psychotic disorder
(5) anxiety disorder
Concomitant prescriptions:
(1) atypical antipsychotic medication (likelihood ratio 17)
(2) anxiolytic
(3) tricyclic or other antidepressant
(4) anticonvulsant
