Kallas et al identified factors associated with mortality in patients with yellow fever. These can help to identify a patient who may require more aggressive management. The authors are from multiple institutions in Brazil.
Patient selection: yellow fever
Key features:
(1) absolute neutrophil count per microliter
(2) viral load in LOG10 copies per mL
Absolute Neutrophil Count
Viral Load
Mortality Rate
>= 4,000
>= 5.1
100%
< 5.1
29%
< 4,000
>= 5.1
38%
< 5.1
11%
Additional predictors of mortality:
(1) age >= 45 years of age
(2) serum AST >= 3500 U/L
(3) INR >=1.46
(4) serum indirect bilirubin >= 0.64 mg/dL
(5) serum creatinine >= 2.36 mg/dL
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