Higgins et al evaluated factors associated with death or new disability following an ICU admission with mechanical ventilation. These factors can help to identify a patient who may require more aggressive management (or palliative care). The authors are from multiple institutions in Australia and Brazil.
Patient selection: age 49-71 years (median 62); ICU admission on mechanical ventilation > 24 hours
Outcome: death or new disability by 6 months (59%)
Definition of disability: increase in WHODAS percentage >= 10% from baseline
Predictors of death or new disability:
(1) age (OR 1.02; will adjust based on lowest age of 44 years)
(2) APACHE III (OR 1.02; maximum score around 299)
(3) admission diagnosis (see below)
Admission diagnosis:
(1) surgical (OR 1)
(2) cardiac arrest (OR 4.1)
(3) sepsis (OR 2.4)
(4) trauma (OR 6.2)
(5) lung transplant (OR 0.2)
(6) other (OR 1.5)
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