Hata et al identified factors associated with an increased risk for malignancy in a woman with an ovarian tumor. The authors are from Shimane Medical and Kagoshima Universities in Japan.
Parameters:
(1) serum CA125 in U/mL (radioimmunoassay, Centocor, Tokyo)
(2) peak systolic velocity (PSV) in cm/s on Doppler ultrasonography (correlates with neovascularization)
Parameters
Finding
Points
serum CA 125
< 35 U/mL
0
>= 35 U/mL
1
peak systolic velocity (PSV)
< 10.4 cm/s
0
>= 10.4 cm/s
1
total number of risk factors for malignancy =
= SUM(points for the 2 parameters)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 2
• The risk of cancer increases with the number of risk factors present.
• These findings can be combined with the ultrasonographic features.to determine the risk of malignancy.
Limitations:
• An elevated CA125 is seen in almost 25% of benign ovarian tumors (Table 6). A normal CA125 was seen in 36% of malignant tumors, mostly those that are Stage I.
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