Hasper et al identified prognostic factors associated with neurologic outcome following cardiac arrest. These can help to identify patients with better or worse prognosis. The authors are from Charite-Universitatsmedizin Berlin.


Outcome: neurological outcome good (Cerebral Performance Category 1 or 2) vs poor (CPC 3 to 5)


Prognostic factors:

(1) difference in serum creatinine on admission and at 24 hours after admission

(2) serum NSE (neuron specific enolase) at 72 hours


change in serum creatinine =

= (serum creatinine in mg/dL at 24 hours) - (serum creatinine in mg/dL on admission)


Prognostic Factors



change in serum creatinine at 24 hours

< - 0.19 mg/dL

>= 0 mg/dL

serum NSE at 72 hours after admission

<= 24 µg/L

>= 29 µg/L



• A drop in creatinine after admission is associated with a good prognosis.


Other factors associated with a better prognosis:

(1) use of therapeutic hypothermia

(2) ventricular fibrillation as initial rhythm

(3) bystander CPR


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