Harteman et al identified findings in a mother or neonate which may be indicators of arterial ischemic stroke in a neonate. The authors are from Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.

Patient selection: full-term neonate


Target: perinatal arterial ischemic stroke (PAIS)


Predictors from multivariate analysis:

(1) maternal fever > 38°C (odds ratio 10.2)

(2) early-onset sepsis (EOS) and/or meningitis (odds ratio 5.8)

(3) hypoglycemia < 2 mmol/L (odds ratio 13.0)

(4) Apgar score at 5 minutes < 7 (odds ratio 18.1)


Additional findings seen in the univariate analysis:

(1) fetal heart rate decelerations

(2) meconium-stained amniotic fluid

(3) emergency caesarean section

(4) umbilical artery pH < 7.10

(5) Apgar score at 1 minute <= 3

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