Gonzalez et al identified risk factors for premature gonadal failure in women with systemic lupus erythematosus (SLE). These can help identify women who may experience problems in conception. The authors are from the University of Alabama in Birmingham, University of Puerto Rico, and the University of Texas in Houston.


Patient selection: premenopausal women < 40 years of age with SLE


Risk factors for premature gonadal failure:

(1) older age

(2) moderate to severe disease activity as measured with SLAM-R (SLAM revised)

(3) Texas-Hispanic or Afro-American ethnicity

(4) cyclophosphamide therapy

(5) antiphospholipid antibodies (lupus anticoagulant, anticardiolipin antibodies)



• No cutoff was given for age. For the implementation > 30 will be used.


The more risk factors that are present the greater the risk of premature gonadal failure.


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