Predictors of Garcia-Vidal et al for a Late Invasive Fungal Infection in an Allogeneic Hematopoietic Stem Cell Transplant Recipient

Description

Garcia-Vidal et al identified risk factors associated with a late invasive fungal infection in a recipient of a hematopoietic stem cell transplant. These can help identify a patient who may benefit from more aggressive management. The authors are from the Fred Hutchinson Cancer Research Center at the University of Washington, Oregon Health and Science University and Hospital Universitari de Bellvitge (Barcelona).

A late mold infection was defined as one occurring 40 or more days after the transplant.

Parameters:

(1) gender

(2) age of the recipient

(3) cytomegalovirus (CMV) infection

(4) blood transfusion

(5) acute graft-vs-host disease (GVHD)

(6) corticosteroid dose

Parameter	Finding	Points
gender of the patient	female	0
	male	1
age of the recipient	younger	0
	older	1
CMV infection	absent	0
	present	1
blood transfusion	none or few	0
	many	1
acute GVHD	absent	0
	present	1
corticosteroid dose	< 2.0 or >= 3.0 mg/kg/day	0
	2.0 to 2.9 mg/kg/day	1

where:

• The adjusted hazard ratio for age was 1.4 for each 10 years.

number of risk factors for a late mold infection =

= SUM(points for all 6 parameters)

Interpretation:

• minimum number of risk factors: 0

• maximum number of risk factors: 6

• The risk of a late mold infection increases with the number of risk factors present.

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Description

Specialty

ICD-10