IVIG responders had fever defervescence within 5 days of starting high-dose IVIG therapy. If fever persisted to the sixth day or longer, then the person was considered a non-responder. About 13% of children will be nonresponders.
IVIG doses ranged from 300 mg/kg for 4-5 days to 400 mg/kg for 3-5 days.
Parameters:
(1) serum levels of C-reactive protein (CRP)
(2) serum lactate dehydrogenase (LDH)
(3) hemoglobin
A person was considered a non-responder if one or more of the following was present on admission to the hospital:
(1) CRP > 10 mg/dL
(2) serum LDH > 590 IU/L
(3) hemoglobin < 11 g/dL
A person who was a non-responder:
(1) is at higher risk for coronary artery aneurysms
(2) should receive additional anti-inflammatory therapy at an early stage of disease
Performance:
• The sensitivity was 85% and specificity 86% for identifying nonresponders.
Limitations:
• The normal reference range and method for LDH were not specified. A value of 590 IU/L was considered to be significantly higher than normal.
