De Bisschop et al reported predictors of extubation failure in preterm infants with neonatal respiratory distress syndrome. These can help to identify a neonate who requires more care during extubation trials. The authors are from Vrije Universiteit Brussel and Universite Libre de Bruxelles.
Study: meta-analysis
Patient seletction: preterm neonate with neonatal respiratory distress syndrome, treated with surfactant using the INSURE procedure.
Predictors of extubation failure:
(1) low body weight (less than 750 to 1,000 grams)
(2) low gestational age (< 26 weeks)
(3) severe respiratory distress (based on chest X-ray or biomarkers)
Additional factors:
(1) low serum hemoglobin (< 14 g/dL)
(2) PaCO2 > 50 mm Hg
(3) PaO2 to FIO2 ratio (< 200)
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