Predictors of Das et al for Downstaging a Rectal Cancer Treated with Preoperative Chemoradiation

 

Parameters:

(1) percent of rectal circumference involved by tumor

(2) distance from distal edge of the tumor to the anal verge in cm

(3) serum CEA concentration

Parameter	Finding	Points
percent of circumference	<= 60%	1
	> 60%	0
distance to anal verge	<= 5 cm	1
	> 5 cm	0
serum CEA	<= 2.5 ng/mL	1
	> 2.5 ng/mL	0

 

total number of favorable prognostic factors =

= SUM(points for all 3 factors)

 

Interpretation:

• minimum number of prognostic factors: 0

• maximum number of prognostic factors: 3

• The greater the number of prognostic factors the better the outcome from preoperative chemoradiation.

• The highest rate of complete response was 27% which was seen with a low serum CEA and small tumor (small circumferential extent).