Patient selection: adolescent or young adult identified as high clinical risk for psychosis using the Structured Interview for Prodromal Syndromes (SIPS) criteria.
35% of patients in the study developed psychosis during the 2.5 year follow-up period.
Predictors:
(1) genetic risk for schizophrenia with deterioration in social, role and/or psychological functioning in the past year
(2) higher level of unusual thought content
(3) higher level of paranoia or suspicion
(4) a higher level of social impairment
(5) history of substance (drug and/or alcohol) abuse
Combinations having the highest Youden score (30 out of 100):
(1) item 1 and 3
(2) item 1 and 4
(3) item 3 and 4
(4) items 1 and 3 and 4
Combinations with 2 items performed as well as combinations with more items.
Performance:
• The sensitivities range from 48 to 67% and the specificities from 63 to 82%.
• The highest Youden index was 30 out of 100, which is mediocre.
