Patient selection: after cancer chemotherapy
Outcome: platelet transfusion
Parameters from a logistic regression model:
(1) platelet count per microliter on day 1 before chemotherapy
(2) absolute lymphocyte count on day 1 before chemotherapy
(3) type of cancer chemotherapy
(4) ECOG performance status
High risk chemotherapy regimens - one of the following:
(1) > 90 mg per square meter doxorubicin per course
(2) > 90 mg per square meter epirubicin per course
(3) > 100 mg per square meter cisplatin per course
(4) > 9 g per square meter ifosfamide per course
(5) > 1 g per square meter cyclophosphamide per course
(6) > 500 mg per square meter etoposide per course
(7) > 1 g per square meter cytarabine per course
|
Parameter
|
Finding
|
Points
|
|
platelet count
|
>= 150,000 per µL
|
0
|
|
|
< 150,000 per µL
|
1
|
|
absolute lymphocyte count
|
> 700 per µL
|
0
|
|
|
<= 700 per µL
|
1
|
|
type of chemotherapy
|
high risk
|
1
|
|
|
not high risk
|
0
|
|
ECOG performance stagus
|
0 or 1
|
0
|
|
|
2 to 4
|
1
|
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the greater the need for platelet transfusion.
|
Total Score
|
Percent Receiving Platelet Transfusions
|
|
0
|
1.5%
|
|
1
|
7%
|
|
2
|
13%
|
|
>= 3
|
45%
|
