Avasare et al reported factors associated with recurrence of IgA nephropathy following a renal transplant. These can help to identify a patient who may require more aggressive management. The authors are from Columbia University, Cleveland Clinic, and New York-Presbyterian Hospital.
Patient selection: status post renal transplant for IgA nephropathy
Prevalence in study:22%
Mean time to recurrence: 2.75 years
Predictors of recurrent disease from multivariate analysis:
(1) young age at diagnosis (HR 0.91)
(2) burden of crescents in glomeruli in biopsy of the native kidney (HR 1.2 per 10% increase in crescents; in Figure 2 >= 10% crescents associated with higher risk and in text > 50% is high risk)
(3) allograft rejection (HR 3.6)
In addition, ethnicity may play a role with a higher proportion of cases seen in Blacks and Hispanics.
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