Annamalai identified predictors for mortality for patients with cirrhosis in the intensive care unit (ICU). These include the MELD score as well as other measure of organ failure. The authors are from Cedars-Sinai Medical Center in Los Angeles.
Patient selection: cirrhosis in ICU
Outcome: mortality
Parameters:
(1) MELD (10-fold modification)
(2) CRRT (continous renal replacement therapy)
(3) vasopressors
(4) mechanical ventilation
Parameters
Findings
Adjusted OR
MELD score
(1.05)^(MELD)
CRRT
no
1
yes
2.43
vasopressors
no
1
yes
3.87
mechanical ventilation
no
1
yes
4.55
cumulative product of adjusted odds ratio
= PRODUCT(4 parameters)
Interpretation:
• minimum cumulative odds ratio: 1
• maximum cumulative odds ratio: around 500
• The higher the score the greater the mortality.
Performance:
• The area under the ROC curve is 0.87.
• The MELD score alone was less predictive.
To read more or access our algorithms and calculators, please log in or register.
