Predictors of Adda et al for Noninvasive Ventilation Failure in a Patient with a Hematologic Malignancy

 

Failure of NIV indicates the need for intubation.

 

Predictors identified on multivariate analysis:

(1) respiratory rate while receiving NIV [OR 1.18 for each breath per minute, 1.18^(breaths per minute)]

(2) number of days between ICU admission and initiation of NIV [OR 2.0 per day, or 2^(days)]

(3) need for vasopressors (OR 6.5)

(4) need for renal replacement therapy (OR 18.3)

(5) diagnosis of the adult respiratory distress syndrome (ARDS) when starting NIV (OR 77.7)

 

cumulative odds ratio =

= PRODUCT(OR for each of the predictors)

 

where:

• Items 3, 4 and 5 indicate organ failures.

• As shown in Figure 3, patients with successful NIV had a 25% cumulative rate of survival at 30 days. Those who failed NIV fared even worse.