Poottasane et al reported a simple score based on blood count parameters to identify a patient with fever who may be infected with dengue. The authors are from Thammasat University in Thailand.
Patient selection: acute fever, presumably in a region where dengue is found
Parameters:
(1) white blood cell count in 10^9/L
(2) platelet count in 10^9/L
(3) monocyte distribution width (MDW) in percent
Parameter
Finding
Points
WBC count
< 4 * 10^9/L
1
>= 4 * 10^9/L
0
platelet count
< 100 * 10^9/L
1
>= 100 * 10^9/L
0
MDW
<= 24%
0
> 24%
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• A score >= 1 had a sensitivity of sensitivity of 0.92 and specificity of 0.41 in the training cohort.
Performance:
• The area under the ROC curve was 0.84 for the training and 0.74 in the validation cohorts.
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