Patient selection: cirrhosis
Parameters:
(1) clinically detectable ascites
(2) history of overt hepatic encephalopathy
(3) simplified animal naming test (S-ANT1), from 0 to 38
(4) serum albumin concentration in g/L, from 0 to 5
(5) activity subdomain of Chronic Liver Disease Questionnaire (CLDQ), from 3 to 21
points for serum albumin =
= (-0.5 * (albumin)) + 25
points for S-ANT1 =
= (-2 * (S-ANT1)) + 76
points for CLDQ activity =
= (-1 * (CLDQ)) + 21
|
Parameter
|
Finding
|
Points
|
|
ascites
|
no
|
0
|
|
|
yes
|
12
|
|
history overt HE
|
no
|
0
|
|
|
yes
|
8
|
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 139
• The higher the score the greater the risk of hepatic encephalopathy.
|
Score
|
Risk
|
|
< 53.5
|
low
|
|
53.5 to 57.5
|
intermediate
|
|
> 57.5
|
high
|
Performance:
• The area under the ROC curve was 0.91 in the derivation and 0.87 in validation cohorts.
