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Predictive Factors of Petric et al for Malignancy in a Follicular Neoplasm of the Thyroid

Description

Petric et al reported factors predictive of malignancy in a follicular neoplasm of the thyroid gland. These can help to identify a patient who may benefit from more aggressive management. The authors are from the Institute of Oncology in Ljubljana, Slovenia.


 

Patient selection: follicular neoplasm on fine needle aspiration of the thyroid

 

Parameters:

(1) age

(2) number of thyroid nodules

(3) preoperative serum thyroglobulin in ng/mL (DYNO immunoradiometric test, Henning)

Parameters

Findings

Odds Ratio

age in years

<= 45 years

1.9

 

> 45 years

1

number of thyroid nodules

1

1.7

 

2 or more

1

preoperative serum thyroglobulin

<= 400 ng/mL

1

 

> 400 ng/mL

2.4

 

cumulative odds ratio for malignancy =

= PRODUCT(odds ratios for the 3 risk factors)

 

Interpretation:

• minimum cumulative odds ratio: 1

• maximum cumulative odds ratio: 7.8

• The higher the cumulative odds ratio the more likely that the nodule is malignant.

 


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