Joy et al evaluated patients who have overdosed on amisulpride and correlated onset of torsade de pointes with the QT interval. The authors are from the University of Otago in New Zealand and Calvary Mater Newcastle Hospital in Australia.

Patient selection: overdose of amisulpride (an atypical antipsychotic drug)


Outcome: torsade de pointes


In Figure 2 the authors correlated probability of torsade with the QT interval in seconds (uncorrected).


value of X =

= (0.029528 * (interval)) - 18.989


probability of torsade de pointes =

= 1 / (1 + EXP((-1) * X))

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