Prediction of Mortality in a Patient with Cystic Fibrosis Based on Body Weight and FEV1

Description

Sharma et al evaluated the impact of malnutrition with wasting on survival in patients with cystic fibrosis. The authors are from Royal Brompton Hospital, Imperial College London and Max-Delbruck-Centrum for Molecular Medicine.

Patient selection: 7 to 45 years (mean age 21 years)

Parameters:

(1) ideal body weight (IBW)

(2) current body weight (CBW)

(3) FEV1 in liters

(4) predicted FEV1 in liters

body weight as percent of ideal body weight =

= (current body weight) / (ideal body weight) * 100%

FEV1 as percent of predicted FEV1 =

= (FEV1) / (predicted FEV1)

CBW as Percent IBW	Mortality Rate
> 110%	(0.002173 * ((FEV1)^2)) – (0.6292 * (FEV1)) + 55.89
90 to 110%	(0.001637 * ((FEV1)^2)) – (0.5724 * (FEV1)) + 65.51
85 to 89.9%	(0.001283 * ((FEV1)^2)) – (0.5426 * (FEV1)) + 73.19
80 to 84.9%	(0.001908 * ((FEV1)^2)) – (0.7108 * (FEV1)) + 87.99
< 80%	(-0.1446 * (FEV1)) + 84.73

where:

• The range for FEV1 as percent of predicted was from 10 to 130%.

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Prediction of Mortality in a Patient with Cystic Fibrosis Based on Body Weight and FEV1

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