Description

Acute myocardial infarction is associated with early mortality despite modern advances in therapy. In patients who are candidates for thrombolytic therapy, it is possible to assess a patient's risk of death within 30 days after an acute myocardial infarction. This is based on analysis of patients in the GUSTO-I trial.


Parameter

Finding

Value

constant

 

3.812

age in years

 

0.07624* (age)

Killip class

1

0

 

2

2.0796

 

3

3.6232

 

4

4.0392

Killip class and age

1

0

 

2

-0.02124 * (age)

 

3

-0.03494 * (age)

 

4

-0.03216 * (age)

systolic blood pressure

systolic BP >= 120

-0.03976*120

 

systolic BP < 120

-0.03976 * (systolic BP)

heart rate

 

MAX((0.03936 * ((heart rate) - 50)),0) - (0.02113 * (heart rate) )

location of MI

inferior

-0.5355

 

location not inferior or anterior (posterior, lateral or apical)

-0.2598

height in centimeters

 

(see below)

weight in kilograms

 

-0.007379 * (weight)

time to treatment in hours

<= 2 hours

2 * 0.09299

 

> 2 hours

(hours) * 0.09299

smoking history

current

-0.2190

 

former

-0.2129

history of diabetes

present

0.2497

 

absent

0

history of hypertension

present

0.1645

 

absent

0

history of cerebrovascular disease

present

0.3412

 

absent

0

history of previous MI

present

0.4115

 

absent

0

history of CABG

present

0.3524

 

absent

0

treatment modality

streptokinase + TPA + IV heparin

0.1399

 

streptokinase + IV heparin

0.2142

 

streptokinase + subcutaneous heparin

0.1968

 

height related values =

= (-0.03972 * (height))+ A - B+ C - D + E

 

A = (0.0001835 * (((height) - 154.9)^3)) if value > 0, else 0

B = (0.0008975 * (((height) - 165.1)^3)) if value > 0, else 0

C = (0.001587 * (((height) - 172)^3)) if value > 0, else 0

D = (0.001068 * (((height) - 177.3)^3)) if value > 0, else 0

E = (0.0001943 * (((height) - 185.4)^3)) if value > 0, else 0

 

L =

= (value for constant)+ (value for age)+ (value for Killip class)+ (value for Killip class & age)+ (value for systolic blood pressure)+ (value for heart weight)+ (value for location of MI)+ (value for height)+ (value for weight)+ (value for time to treatment)+ (value for smoking history)+ (value for diabetes history)+ (value for hypertension history)+ (value for previous MI)+ (value for CABG)+ (value for treatment modality)

 

probability of mortality within 30 days of an acute MI =

= (1 / (1 + (EXP (-L))))

 


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