Dionigi et al used their modification of Elebute and Stoner's Sepsis Score (see previous section) in combination with serum complement factor B levels to predict outcome in surgical patients with sepsis in the intensive care unit (ICU). This can help identify patients who may benefit from more aggressive therapy. The authors are from the University of Pavia in Italy.
Parameters:
(1) Sepsis Score of Dionigi et al
(2) complement Factor B levels (using the Properdin B Factor B reagent kit, Beckman Instruments; reference range not listed)
Sepsis Score
Factor B Level
Percent Survive
Percent Die
< 20
>= 45 mg/dL
100%
0
< 20
< 45 mg/dL
57%
43%
>= 20
>= 40 mg/dL
33%
66%
>= 20
< 40 mg/dL
0%
100%
based on data in Figure 4, page 276
Limitations:
• The complement factor B levels probably vary with methods, so that the values to use for Factor B will have to be determined in an institution before it is used.
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