Description

The bone mineral content (BMC) of children can be estimated if certain physical measurements are available. The estimates can allow comparison of the BMC among healthy children of different body sizes and racial backgrounds. The authors are from Baylor College of Medicine and the Texas Children's Hospital in Houston.


 

Children: ages 5 to 18 years (446 male, 1125 female)

 

Measurements:

(1) anthropometric examination

(2) whole body DXA scan (for bone area, lean tissue mass, fat and percent body fat, bone mineral content and bone mineral density).

 

Parameters with point assignments:

(1) sex

(2) race

Parameter

Finding

Points

sex

female

0

 

male

1

race

Black

-1

 

Hispanic

1

 

White

0

 

The first method based on the physical examination:

 

A =

= ((body height in cm) ^ 2.31) * 0.001 * ((1.75 * (points for sex)) + 6.98)

 

B =

= (16.4 * (weight in kilograms)) + (37.7 * (age in years)) – (77.3 * (points for sex)) – (45.8 * (points for race)) - 503

 

bone mineral content in grams by Method 1 =

= A + B

 

If DEXA scanning data is also available, a second method can be used:

 

C =

= LN(bone area in square cm) * (1.37 – (0.068 * (points for sex)))

 

D =

= (0.002 * (lean tissue mass in kg)) – (0.003 * (percent body fat)) + (0.47 * (points for sex) – 2.81

 

LN (bone mineral content in grams) =

= C + D

 

bone mineral content in grams by Method 2 =

= EXP(C + D)

 

where:

• Percent body fat is a number between 0 and 100.

• I am not sure what normal values for the bone area can be expected.

 

Performance measures:

• r^2 for Method 1 is 0.936, with SEE 160 grams

• r^2 for Method 2 is 0.98 and SEE = 0.067

 

Limitations:

• The equations may not be accurate for children with diseases that may affect normal bone growth (AIDS, cystic fibrosis, liver failure, cancer, growth hormone deficiency, etc.)

 


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