Description

Trebicka et al reported common precipitating events for acute decompensation in a patient with cirrhosis. This can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in Europe and belong to the PREDICT STUDY group of the EASL-CLIF Consortium.


Patient selection: cirrhosis

 

A cirrhotic patient with acute decompensation may present with or without acute-on-chronic liver failure (ACLF).

 

Common precipitants:

(1) proven bacterial infection

(2) severe alcoholic hepatitis

(3) gastrointestinal bleeding with shock

(4) toxic encephalopathy (drug-induced brain injury)

 

Other factors:

(1) paracentesis without albumin

(2) acute viral hepatitis

(3) toxic hepatitis

(4) TIPS

 

Although not listed, shock from a cause other than sepsis or GI bleeding would also qualify.

 

Identifying the precipitating cause and treating it promptly can improve outcomes. Adequate first-line antibiotic therapy of proven bacterial infections are associated with better outcomes.


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