Features of post-infectious EBV-associated cerebellitis:
(1) evidence of a recent Epstein-Barr viral infection (infectious mononucleosis)
(2) evidence of cerebellar involvement with motor changes (ataxia, altered speech, etc) and/or cognitive changes
(3) features of post-infectious cerebellitis (see below)
(4) exclusion of other conditions (acute EBV-related encephalitis, etc)
Features of post-infectious cerebellitis:
(1) interval between onset of clinical signs of the preceding infection and the onset of cerebellar findings
(2) normal MRI scan of the brain
(3) abnormal cerebellar perfusion on SPECT (single photon emission computed tomography) scan (hypoperfusion or hyperperfusion)
Management may include:
(1) high dose corticosteroids
(2) intravenous infusion of immune globulins (IVIG)
(3) plasmapheresis
