Description

Mease et al identified factors associated response to abatacept therapy in a patient with psoriatic arthritis. The authors are from University of Washington, University of Glasgow, Stanford University, and St. Vincent's University Hospital (Dublin).


Patient selection: psoriatic arthritis

 

Response: measured with ACR20 (American College Rheumatology criteria for 20% improvement).

 

Factors associated with a positive response to abatacept therapy:

(1) elevated C-reactive protein (> 3 mg/L)

(2) high DAS-28 score (DAS28 using CRP > 5.1)

(3) dactylitis

(4) >= 3 joint erosions

 

These factors are recognized as factors associated with poor prognosis or disease progression.


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