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Polymorphism Information Content (PIC)

Specialty:

Genetics

Objective:

ICD-10:

Description:

Polymorphism Information Content (PIC) is a measure of the informativeness of a genetic marker that is similar to the heterozygosity index but which subtracts the probability of uninformative matings. It is useful for the situation of a rare dominant disease where one of the parents is heterozygous for the disease allele. The PIC is defined as the probability that the marker genotype of a given offspring will allow deduction of which of the two marker alleles of the affected parent it had received (Ott, page 29).

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