Tefferi et al reported a risk score for patients with polycythemia vera (PV). This can help to identify a patient who may benefit from more aggressive management. The authors are from the United States and Europe.
Patient selection: polycythemia vera
Outcome: overall survival
Parameters:
(1) age in years
(2) leukocyte count in 10^9/L
(3) venous thrombosis
Parameters
Findings
Points
age in years
< 57 years
0
57 to 66 years
2
>= 67 years
5
leukocyte count
< 15 * 10^9/L
0
>= 15 * 10^9/L
1
venous thrombosis
no
0
yes
1
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 7
• The higher the score the worse the survival.
• Pruritis is a favorable risk factor for overall survival.
Total Score
Risk Group
Median Survival
0
low
27.8 years
1 or 2
intermediate
18.9 years
3 to 7
high
10.9 years
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