Description

The poison hemlock (Conium maculatum) has been associated with human poisoning through the ages, including the death of Socrates. It is a large biennial (lives 2 years) herb.


 

Synonym: spotted hemlock, spotted parsley, fool's parsley, St. Bennet's herb, spotted cowbane

 

Features of the plant:

(1) Young plants have fernlike leaves that are light-green in color.

(2) More mature plants have purple spots on larger stems.

(3) The plant has a long white taproot.

 

Toxin: coniine, gamma-coniceine and related piperidine alkaloids

 

Primary effects:

(1) nondepolarizing blockage of the neuromuscular junction

(2) nicotinic effect on autonomic ganglia

(3) rhabdomyolysis

 

Clinical findings with neuromuscular blockade:

(1) flaccid muscular paralysis

(2) muscle fasciculations

(3) respiratory failure

 

Clinical findings with nicotinic action:

(1) salivation

(2) mydriasis

(3) tachycardia initially, followed by bradycardia

 

Clinical findings with rhabdomyolysis:

(1) myalgias

(2) myoglobinuria

(3) elevated serum CK

(4) acute renal failure

 

Other findings:

(1) nausea and vomiting

(2) cold shivers

 

Interestingly, human intoxication may occur after ingestion of quail that have fed on hemlocks seeds (Van Veen).

 


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