Criteria for Methotrexate-Induced Pneumonitis

Temperature

Did the patient have an acute onset of shortness of breath?

Respiratory rate

Does the patient have a nonproductive cough?

Does the chest X-ray show interstitial or alveolar infiltrates?

WBC count

Are blood and sputum cultures negative for pathogenic organisms?

Do pulmonary function tests show a restrictive pattern with decreased diffusion capacity?

PaO2 in mm Hg on room air at time of admission

Does histologic examination of a lung biopsy show either bronchiolitis or interstitial pneumonitis with giant cells?

Are pathogenic microorganisms seen on histologic examination of a lung biopsy?