Description

The platelet-to-lymphocyte ratio (PLR) is a marker of inflammation.


Basis: Reactive thrombocytosis may occur with tumors. Lymphocytopenia is associated with immune defects.

 

Parameters:

(1) platelet count

(2) absolute lymphocyte count

 

platelet to lymphocyte ratio =

= (platelet count) / (absolute lymphocyte count)

 

Interpretation:

• An elevated PLR is associated with worse prognosis for several malignancies, with cutoffs ranging from 150 to 300.

• A PLR >= 140 is associated with increased inflammation in end-stage renal disease.

• A PLR >= 150 is associated with IVIG resistance in Kawasaki disease.

 

Performance:

• Chemotherapy and infection can affect both platelet and lymphocyte counts.


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