Quaglietta et al developed a score for predicting whether platelet transfusions will be efficaceous in a hematology-oncology patient. The authors are from Civil Hospital and the Center for Outcomes Research and Clinical Epidemiology in Pescara, Italy.
Patient selection: thrombocytopenic hematology-oncology patient
Outcome: absolute increment in platelet count >= 10.5 *10^9/L (10,5000 per µL)
Parameters:
(1) diagnosis
(2) gender
(3) number of platelet transfusions
(4) platelet antibodies and crossmatch
(5) ABO compatibility
(6) dose of platelets infused in 10^11/L
(7) days of storage per day (from 0 to 5)
(8) pathogen inactivation
(9) split unit
(10) plasma reduction
|
Parameter |
Finding |
Points |
|
diagnosis |
acute leukemia |
0 |
|
|
myelodysplasia |
-2 |
|
|
aplastic anemia |
3 |
|
|
malignant lymphoma |
-1 |
|
|
chronic leukemia |
-2 |
|
|
myeloma |
0 |
|
|
solid tumors |
0 |
|
gender |
female |
0 |
|
|
male |
-1 |
|
number of platelet transfusions |
< 25 |
1 |
|
|
>= 25 |
0 |
|
platelet antibodies and crossmatch |
antibody testing not performed |
0 |
|
|
antibody positive, crossmatch positive |
-9 |
|
|
antibody positive, crossmatch negative |
-3 |
|
|
antibody positive, crossmatch not performed |
-5 |
|
|
antibody negative, crossmatch not performed |
-2 |
|
ABO compatibility |
identical |
0 |
|
|
compatible |
0 |
|
|
incompatible |
-2 |
|
dose of platelets |
<= 2 * 10^11/L |
0 |
|
|
2.01 to 3.00 * 10^11/L |
1 |
|
|
3.01 to 4.00 * 10^11/L |
2 |
|
|
4.01 to 5.00 * 10^11/L |
4 |
|
|
> 5 * 10^11/L |
5 |
|
days of storage |
|
(-1) * (days) |
|
pathogen inactivation |
no |
1 |
|
|
yes |
0 |
|
unit split |
no |
0 |
|
|
yes |
-2 |
|
plasma reduction |
no |
1 |
|
|
yes |
0 |
where:
• The data for number of platelet transfusions did not provide for an "equal to 25".
• Hodgkin's disease not specified in table.
score =
= MIN(30,SUM)points for all parameters) + 21)
Interpretation:
• minimum score: 0
• maximum score: 30
• The higher the score the greater the chances that the platelet transfusion will be a success.
|
Score |
Percent Success |
|
0 or 1 |
0% |
|
2 to 12 |
(0.0641 * ((score)^2)) - (0.1483 * (score)) + 0.2564 |
|
12 to 26 |
(0.1292 * ((score)^2)) + (0.2613 * (score)) - 15.02 |
|
26 to 30 |
(-0.3571 * ((score)^2)) + (23.2 * (score)) - 284.6 |
Specialty: Clinical Laboratory, Hematology Oncology
