If a continuous infusion is started without a bolus, then the plasma level will rise gradually to the steady state level. The plasma level during this rise can be estimated based on the patient's kinetic data.
plasma drug concentration in amount per volume =
= (target steady state concentration in amount per volume) * (1 - EXP((-1) * (elimination rate constant per hour) * (hours since starting the infusion)))
where:
• The target steady state concentration for the infusion is calculated in the previous section.
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