Casasnovas et al developed a prognostic score for a patient with classic Hodgkin's disease based on plasma levels of various cytokines and soluble receptors. It provides independent prognostic information for the patient. The authors are from the Groupe d'Etude des Lymphomes de l'Adulte in France.
Parameters:
(1) IL1-RA (interleukin-1 receptor antagonist, IL-1F3)
(2) interleukin 6 (IL-6)
(3) soluble CD30
|
Analyte |
Assay |
Level of Detection |
|
IL1-RA |
R & D System (www.rndsystems.com) |
22 pg/mL |
|
IL-6 |
Beckman-Coulter |
3 pg/mL |
|
soluble CD30 |
Dako |
1 U/mL |
|
Parameter |
Findings |
Points |
|
IL1-RA |
<= 668 pg/mL |
0 |
|
|
> 668 pg/mL |
1 |
|
IL-6 |
<= 30 pg/mL |
0 |
|
|
> 30 pg/mL |
1 |
|
soluble CD30 |
<= 80 U/mL |
0 |
|
|
> 80 U/mL |
1 |
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse prognosis.
|
Total Score |
5 Year Overall Survival |
5 Year Event Free Survival |
|
0 |
95% |
92% |
|
1 |
93% |
85% |
|
2 |
82% |
75% |
|
3 |
63% |
15% |
Specialty: Hematology Oncology
