Placental Changes of Maternal Uteroplacental Vascular Compromise (UPVC)

 

Criteria for UPVC - one or both of the following:

(1) placental infarction (s)

(2) histologic score

 

Placental infarcts indicative of UPVC - at least one infarct that is:

(1) > 2 cm from the edge of the placenta (nonmarginal)

(2) volume > 1 cubic cm (spherical infarct with a diameter > 1.25 cm)

 

Parameters for histologic score:

(1) syncytial knotting

(2) syncytial basophilia

(3) villous fibrosis

(4) excess perivillous fibrin deposition with cytotrophoblast proliferation

Degree for Each Parameter	Points
none	0
minimal to mild	1
moderate	2
moderate to marked	3
marked	4

 

total histologic score =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum histologic score: 0

• maximum histologic score: 16

• A score >=8 was indicative of UPVC.