PILE Score in a Patient Treated with Anti-PD-1 or Anti-PD-L1 Inhibitors

PILE is acronym for PIV, LDH and ECOG.

Parameters prior to administration of first dose of immune checkpoint inhibitor):

(1) blood PIV (Pan-Immune-Inflammation Value)

(2) median value for blood PIV

(3) serum LDH in U/L

(4) upper limit of normal (ULN) for serum LDH

(5) ECOG status

PILE score =

= SUM(points for all 3 parameters)

Interpretation:

• minimum score: 0

• maximum score: 3

• A score of 2 or 3 is high risk and is associated with a decreased overall survival.

Performance:

• The area under the ROC curve is 0.65 for overall survival.