Sachdev et al reported a mortality risk score for a patient with sickle cell disease. The authors are from the National Heart, Lung and Blood Institute at NIH.
Patient selection: sickle cell anemia
Parameters:
(1) tricuspid regurgitation velocity (TRV) in m/s
(2) body mass index (BMI) in kg per sq meter
(3) heart rate in beats per minute
(4) mitral E velocity in cm/s
(5) right atrial pressure in mm Hg
(6) serum alkaline phosphatase in U/L
(7) septal thickness in mm
(8) age in years
(9) blood urea nitrogen (BUN) in mg/dL
(10) serum NT-proBNP in pg/mL
Data from echocardiography
|
Parameter |
Finding |
Points |
|
TRV |
<= 3 m/s |
0 |
|
|
> 3 m/s |
1 |
|
mitral E velocity |
<= 80 cm/s |
1 |
|
|
> 80 cm/s |
0 |
|
right atrial pressure |
<= 5 mm Hg |
0 |
|
|
> 5 mm Hg |
1 |
|
septal thickness |
<= 10 mm |
0 |
|
|
> 10 mm |
1 |
Data without echocardiography
|
Parameter |
Finding |
Points |
|
BMI |
< 35 kg per sq m |
0 |
|
|
>= 35 kg per sq m |
1 |
|
heart rate |
<= 85 bpm |
0 |
|
|
> 85 bpm |
1 |
|
serum alkaline phosphatase |
<= 90 U/L |
0 |
|
|
> 90 U/L |
1 |
|
age in years |
<= 50 years of age |
0 |
|
|
> 50 years of age |
1 |
|
serum BUN |
<= 20 mg/dL |
0 |
|
|
> 20 mg/dL |
1 |
|
NT-proBNP |
< 160 pg/mL |
0 |
|
|
>= 160 pg/mL |
1 |
simple risk score =
= SUM(points for the first 9 parameters without NT-proBNP)
Interpretation:
• minimum simple score: 0
• maximum simple score: 9 (from online version at dir.nhibi.nih.gov_
|
Total Score |
Risk |
|
0 or 1 |
low |
|
2 or 3 |
intermediate-1 |
|
4 |
intermediate-2 |
|
5 to 9 |
high |
Specialty: Hematology Oncology
