Phenotypes of Moore et al for Asthma (SARP Algorithm)

Description

Moore et al used cluster analysis to identify 5 phenotypes in patients with asthma. The phenotypes can help guide management of a patient. The authors participate with the Severe Asthma Research Program (SARP) of the National Heart, Lung, and Blood Institute.

Patient selection: asthma

Parameters:

(1) baseline FEV1 as percent of predicted

(2) maximum FEV1 after 6-8 puffs of albuterol as percent of predicted

(3) age of onset

Baseline FEV1	FEV1 Post	Age of Onset	Cluster
>= 68%	>= 108%	NA	1
>= 68%	< 108%	< 40 years	2
>= 68%	< 108%	>= 40 years	3
< 68%	>= 65%	NA	4
< 68%	< 65%	NA	5

Clusters 4 and 5 were associated with more severe disease. Cluster 5 is associated with fixed airflow (no change with albuterol).

Cluster 1 is associated with relatively mild atopic asthma.

Cluster 2 is associated with mild to moderate atopic asthma.

Cluster 3 is associated with late-onset non-atopic asthma.

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Phenotypes of Moore et al for Asthma (SARP Algorithm)

Description

Specialty