Phenotype frequencies for red blood cell antigens are determined by testing blood samples from a large, random population of people with antibodies to selected antigens. It is essential that the people tested should all be of the same racial makeup.
The proportion of positive and negative reactions are calculated. Ideally the sum of phenotypic frequencies for a given antigen should equal 1.00 (100%).
Based on knowledge of the percentage of people in a uniform population who are positive and negative for a given antigen, it is possible to calculate the percentage of donors who will be compatible (i.e., negative for the antigen) with a patient having an antibody to that antigen.
Antigen
Whites Negative for
Blacks Negative for
C
0.32
0.73
c
0.20
0.04
D
0.15
0.08
E
0.71
0.78
e
0.03
0.01
Fya
0.33
0.89
Fyb
0.17
0.77
Jka
0.25
0.09
Jkb
0.25
0.57
K
0.90
0.97
k
0.002
0.0005
Lea
0.78
0.77
Leb
0.28
0.45
M
0.22
0.30
N
0.28
0.26
P1
0.21
0.06
S
0.45
0.69
s
0.11
0.03
U
0
0.005
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