Pharmacy-Based Comorbidity Index (PBCI) of Sarfati et al for a Patient with Cancer

Description

Sarfati et al developed a comorbidity index based on the patient's medication records. The authors are from Health University of Otago and Capital and Coast District Health Board in Wellington, New Zealand.

Patient selection: cancer

Number of comorbid conditions: 19

The coefficients for each condition is LN(hazard ratio)

Condition	Drugs	Coefficient
anemia	iron therapy, megaloblastic agents, hypoplastic and hemolytic	0.93
anticoagulation	anticoagulant	0.79
antiplatelet drug	antiplatelet drugs	0.46
anxiety, tension	anxiolytics, sedative and hypnotics	0.32
cardiac arrhythmia	antiarrhythmics, digoxin	1.04
CHF	loop diuretic	1.16
depression	antidepressant	0.35
diabetes	insulin, oral hypoglycemic	0.41
epilepsy	anticonvulsant	0.60
gastric acid disorder	H2 blockers, proton pump inhibitors	0.34
hyperlipidemia	anti-lipemic agents	0.15
hypothyroidism	thyroid replacements	0.09
angina	nitrates	0.74
hypertension	beta blockers, calcium channel blockers, ACE inhibitors, antiotensin II inhibitors, thiazides, potassium-sparing agents, anti-hypertensives, clonidine, hydralzine	0.51
bone (osteoporosis, Paget's disease)	alendronate, etidronate	0.53
Parkinson's disease	anti-Parkisonian agetns	0.97
psychosis	antipsychotics	1.06
reactive airway disease	inhaled bronchodilators, leukotriene inhibitors, respiratory devices	0.52
steroid-responsive condition	glucocorticoids	0.54

total score =

= SUM(coefficients for all of the parameters)

Inerpretation:

• minimum score: 0

• maximum score: 11.51

• The higher the score the greater the level of comorbidity.

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