Peters' corneal anomaly affects the anterior chamber with:
(1) central or paracentral corneal opacity (leukoma)
(2) thinning of the posterior aspect of the cornea
(3) iridocorneal adhesions attached to the edges of the leukoma
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Type
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Findings
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Type I
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central or paracentral corneal opacity with adhesions, often unilateral
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Type II
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with lens involvement: lens adherence to the posterior cornea, failure of the lens to completely separate from the cornea and/or cataract; often bilateral
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Some patients may have mutations in PAX6 on chromosome 11p13.
Complications include visual impairment and glaucoma.
Accompanying ocular defects may include:
(1) coloboma (chorioretinal and/or iris)
(2) persistence and hyperplasia of the primary vitreous
(3) microphthalmos
(4) optic nerve hypoplasia
Systemic disorders with Peters' anomaly:
(1) Krause-Kivlin syndrome
(2) Peters'-Plus Syndrome
(3) fetal alcohol syndrome
