Peters' anomaly is a congenital defect in the mesenchyma of the anterior chamber which affects the cornea. It may be found as an isolated finding or as part of a systemic disorder. It is associated with a defect during the first and/or third embryonic neural crest migratory waves.


Peters' corneal anomaly affects the anterior chamber with:

(1) central or paracentral corneal opacity (leukoma)

(2) thinning of the posterior aspect of the cornea

(3) iridocorneal adhesions attached to the edges of the leukoma



Type I

central or paracentral corneal opacity with adhesions, often unilateral

Type II

with lens involvement: lens adherence to the posterior cornea, failure of the lens to completely separate from the cornea and/or cataract; often bilateral


Some patients may have mutations in PAX6 on chromosome 11p13.


Complications include visual impairment and glaucoma.


Accompanying ocular defects may include:

(1) coloboma (chorioretinal and/or iris)

(2) persistence and hyperplasia of the primary vitreous

(3) microphthalmos

(4) optic nerve hypoplasia


Systemic disorders with Peters' anomaly:

(1) Krause-Kivlin syndrome

(2) Peters'-Plus Syndrome

(3) fetal alcohol syndrome


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